Genautica

Richard Kornbluth

Dr. Kornbluth invented the company’s technology while serving as an Associate Professor of Medicine at the University of California San Diego. He is both a basic scientist and a Board Certified medical internist and pulmonary specialist. He received his Bachelor’s degree at Harvard, his M.D. at New York Medical College, and his Ph.D. at Columbia University. During medical school, he took a 1 1/2 year leave of absence to study tumor angiogenesis with Dr. Judah Folkman at Harvard. Dr. Kornbluth's interest in immunostimulatory molecules began during a postdoctoral fellowship in tumor immunology at the Scripps Research Institute where he filed his first patent on what is now known as CD40L. At UCSD, he published more than 50 papers on the immunology and molecular virology of HIV, and wrote or co-wrote 26 successful grant applications. At MultimericBio, Dr. Kornbluth will optimize his multimeric soluble TNFSF technology and help advance its transition to clinical applications in tumor immunotherapy and vaccines.

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References:

Stone GW, Barzee S, Snarsky V, Santucci C, Tran B, Langer R, Zugates GT, Anderson DG, Kornbluth RS (2009) Nanoparticle-delivered multimeric soluble CD40L DNA combined with Toll-Like Receptor agonists as a treatment for melanoma., PloS one, 4 (10), e7334.

Grossmann C, Tenbusch M, Nchinda G, Temchura V, Nabi G, Stone GW, Kornbluth RS, Uberla K (2009) Enhancement of the priming efficacy of DNA vaccines encoding dendritic cell-targeted antigens by synergistic toll-like receptor ligands., BMC immunology, 10, 43.

Liu J, Yu Q, Stone GW, Yue FY, Ngai N, Jones RB, Kornbluth RS, Ostrowski MA (Jul 2008) CD40L expressed from the canarypox vector, ALVAC, can boost immunogenicity of HIV-1 canarypox vaccine in mice and enhance the in vitro expansion of viral specific CD8+ T cell memory responses from HIV-1-infected and HIV-1-uninfected individuals., Vaccine, 26 (32), 4062-72.

Kornbluth RS, Smee DF, Sidwell RW, Snarsky V, Evans DH, Hostetler KY (2006) Mutations in the E9L Polymerase Gene of Cidofovir-Resistant Vaccinia Virus Strain WR Are Associated with the Drug Resistance Phenotype., Antimicrob Agents Chemother., 50 (2), 4038-43.

Stone GW, Barzee S, Snarsky V, Spina CA, Lifson JD, Pillai VK, Amara RR, Villinger F, Kornbluth RS (2006) Macaque Multimeric Soluble CD40 Ligand and GITR Ligand Constructs Are Immunostimulatory Molecules In Vitro., Clin Vaccine Immunol. 2006 Nov;13(11):1223-30. Epub 2006 Sep 20., 13 (11), 1223-30.

Kornbluth RS, Stone GW (2006) Immunostimulatory combinations: designing the next generation of vaccine adjuvants., J Leukoc Biol., 80 (5), 1084-102.

Kornbluth RS (2006) HIV creates an immunologic black hole, Blood, 107 (5), 1743-1744.

Stone GW, Barzee S, Snarsky V, Kee K, Spina CA, Yu XF, Kornbluth RS (2006) Multimeric soluble CD40 ligand and GITR ligand as adjuvants for human immunodeficiency virus DNA vaccines, J Virol, 80 (4), 1772.

Wang JP, Hayashi T, Datta SK, Kornbluth RS, Raz E, Guiney DG (Aug 2005) CpG oligonucleotides partially inhibit growth of Mycobacterium tuberculosis, but not Salmonella or Listeria, in human monocyte-derived macrophages., Fems Immunology and Medical Microbiology, 45 (2), 303-10.

Woelk CH, Ottones F, Plotkin CR, Du P, Royer CD, Rought SE, Lozach J, Sasik R, Kornbluth RS, Richman DD, Corbeil J (Nov 2004) Interferon gene expression following HIV type 1 infection of monocyte-derived macrophages., Aids Research and Human Retroviruses, 20 (11), 1210-22.

Kornbluth RS (1 Mar 2004) Invited Commentary: HIV envelope becomes unhinged by PID for entry, Blood, 103 (1567), 1567.

Kornbluth RS (Oct 2002) An expanding role for CD40L and other tumor necrosis factor superfamily ligands in HIV infection., Journal of Hematotherapy & Stem Cell Research, 11 (5), 787-801.

Brooun A, Richman DD, Kornbluth RS (Dec 2001) HIV-1 preintegration complexes preferentially integrate into longer target DNA molecules in solution as detected by a sensitive, polymerase chain reaction-based integration assay., The Journal of Biological Chemistry, 276 (50), 46946-52.

Hayashi T, Rao SP, Takabayashi K, Van Uden JH, Kornbluth RS, Baird SM, Taylor MW, Carson DA, Catanzaro A, Raz E (Oct 2001) Enhancement of innate immunity against Mycobacterium avium infection by immunostimulatory DNA is mediated by indoleamine 2,3-dioxygenase., Infection and Immunity, 69 (10), 6156-64.

Kornbluth RS (Sep 2000) The emerging role of CD40 ligand in HIV infection., Journal of Leukocyte Biology, 68 (3), 373-82.

Martin-Orozco E, Kobayashi H, Van Uden J, Nguyen MD, Kornbluth RS, Raz E (Jul 1999) Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences., International Immunology, 11 (7), 1111-8.

Hayashi T, Rao SP, Meylan PR, Kornbluth RS, Catanzaro A (Jul 1999) Role of CD40 ligand in Mycobacterium avium infection., Infection and Immunity, 67 (7), 3558-65.

Kornbluth RS, Kee K, Richman DD (Apr 1998) CD40 ligand (CD154) stimulation of macrophages to produce HIV-1-suppressive beta-chemokines., Proceedings of the National Academy of Sciences of the United States of America., 95 (9), 5205-10.

Roman M, Martin-Orozco E, Goodman JS, Nguyen MD, Sato Y, Ronaghy A, Kornbluth RS, Richman DD, Carson DA, Raz E (Aug 1997) Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants., Nature Medicine, 3 (8), 849-54.

Perno CF, Crowe SM, Kornbluth RS (Jul 1997) A continuing enigma: the role of cells of macrophage lineage in the development of HIV disease., Journal of Leukocyte Biology, 62 (1), 1-3.

Crowe SM, Kornbluth RS (Feb 1996) Managing HIV. Part 3: Mechanisms of disease. 3.3 How HIV leads to opportunistic infections., The Medical Journal of Australia, 164 (3), 171-3.

Meylan PR, Kornbluth RS, Zbinden I, Richman DD (Dec 1994) Influence of host cell type and V3 loop of the surface glycoprotein on susceptibility of human immunodeficiency virus type 1 to polyanion compounds., Antimicrobial Agents and Chemotherapy, 38 (12), 2910-6.

Kornbluth RS (Dec 1994) The immunological potential of apoptotic debris produced by tumor cells and during HIV infection., Immunology Letters, 43 (1-2), 125-32.

Crowe SM, Kornbluth RS (Sep 1994) Overview of HIV interactions with macrophages and dendritic cells: the other infection in AIDS., Journal of Leukocyte Biology, 56 (3), 215-7.

Kornbluth RS (Sep 1994) Significance of T cell apoptosis for macrophages in HIV infection., Journal of Leukocyte Biology, 56 (3), 247-56.

von Schwedler U, Kornbluth RS, Trono D (Jul 1994) The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes., Proceedings of the National Academy of Sciences of the United States of America., 91 (15), 6992-6.

Kornbluth RS, Matsuzaki H, Meylan PR, Richman DD (Oct-Dec 1994) Interferon interactions with HIV1 in macrophages., Research in Immunology, 145 (8-9), 664-6; discussion 66.

Kornbluth RS, McCutchan JA (Aug 1993) Skin test responses as predictors of tuberculous infection and of progression in HIV-infected persons., Annals of Internal Medicine, 119 (3), 241-3.

Meylan PR, Guatelli JC, Munis JR, Richman DD, Kornbluth RS (Mar 1993) Mechanisms for the inhibition of HIV replication by interferons-alpha, -beta, and -gamma in primary human macrophages., Virology, 193 (1), 138-48.

Meylan PR, Spina CA, Richman DD, Kornbluth RS (Mar 1993) In vitro differentiation of monocytoid THP-1 cells affects their permissiveness for HIV strains: a model system for studying the cellular basis of HIV differential tropism., Virology, 193 (1), 256-67.

Kornbluth RS, Rhodes J, Richman DD (Feb 1993) Recovery of infectious HIV following the passage of apoptotic cellular debris through phagocytic macrophages., Chest, 103 (2 Suppl), 102S-103S.

Meltzer MS, Kornbluth RS, Hansen B, Dhawan S, Gendelman HE (Feb 1993) HIV infection of the lung. Role of virus-infected macrophages in the pathophysiology of pulmonary disease., Chest, 103 (2 Suppl), 103S-108S.

Pauza CD, Kornbluth R, Emau P, Richman DD, Deftos LJ (Feb 1993) Vitamin D3 compounds regulate human immunodeficiency virus type 1 replication in U937 monoblastoid cells and in monocyte-derived macrophages., Journal of Leukocyte Biology, 53 (2), 157-64.

Kornbluth RS, Rhodes J, Richman DD (Feb 1993) Recovery of infectious HIV following the passage of apoptotic cellular debris through phagocytic macrophages., Chest, 103 (2 Suppl), 102S-103S.

Meylan PR, Richman DD, Kornbluth RS (Aug 1992) Oxygen tensions and mycobacterial infections., Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 15 (2), 372-3.

Munis JR, Kornbluth RS, Guatelli JC, Richman DD (Aug 1992) Ordered appearance of human immunodeficiency virus type 1 nucleic acids following high multiplicity infection of macrophages., The Journal of General Virology, 73 ( Pt 8), 1899-906.

Meylan PR, Richman DD, Kornbluth RS (Apr 1992) Reduced intracellular growth of mycobacteria in human macrophages cultivated at physiologic oxygen pressure., The American Review of Respiratory Disease, 145 (4 Pt 1), 947-53.

Meylan PR, Munis JR, Richman DD, Kornbluth RS (Jan 1992) Concurrent human immunodeficiency virus and mycobacterial infection of macrophages in vitro does not reveal any reciprocal effect., The Journal of Infectious Diseases, 165 (1), 80-6.

Meylan PR, Tam EK, Kornbluth RS, Richman DD (Jan 1992) HIV infectivity is not augmented by treatment with trypsin, Factor Xa or human mast-cell tryptase., Aids (lLondon, England), 6 (1), 128-30.

Terai C, Kornbluth RS, Pauza CD, Richman DD, Carson DA (May 1991) Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1., The Journal of Clinical Investigation, 87 (5), 1710-5.

Kornbluth RS, Munis JR, Oh PS, Meylan PR, Richman DD (Aug 1990) Characterization of a macrophage-tropic HIV strain that does not alter macrophage cytokine production yet protects macrophages from superinfection by vesicular stomatitis virus., Aids Research and Human Retroviruses, 6 (8), 1023-6.

Meylan PR, Richman DD, Kornbluth RS (Aug 1990) Characterization and growth in human macrophages of Mycobacterium avium complex strains isolated from the blood of patients with acquired immunodeficiency syndrome., Infection and Immunity, 58 (8), 2564-8.

Terkeltaub R, Firestein GS, Kornbluth RS, Martin J, Curran D, Manolagas S (Feb 1990) The effects of gamma-interferon on human peripheral blood monocyte/macrophage-mediated bone particle degradation., Bone and Mineral, 8 (2), 131-43.

Kornbluth RS, Oh PS, Munis JR, Cleveland PH, Richman DD (Feb 1990) The role of interferons in the control of HIV replication in macrophages., Clinical Immunology and Immunopathology, 54 (2), 200-19.

Munis JR, Richman DD, Kornbluth RS (Feb 1990) Human immunodeficiency virus-1 infection of macrophages in vitro neither induces tumor necrosis factor (TNF)/cachectin gene expression nor alters TNF/cachectin induction by lipopolysaccharide., The Journal of Clinical Investigation, 85 (2), 591-6.

Kornbluth RS, Oh PS, Munis JR, Cleveland PH, Richman DD (Mar 1989) Interferons and bacterial lipopolysaccharide protect macrophages from productive infection by human immunodeficiency virus in vitro., The Journal of Experimental Medicine, 169 (3), 1137-51.

Kornbluth RS, Gregory SA, Edgington TS (Sep 1988) Initial characterization of a lymphokine pathway for the immunologic induction of tumor necrosis factor-alpha release from human peripheral blood mononuclear cells., Journal of Immunology (baltimore, Md. : 1950), 141 (6), 2006-15.

Richman DD, Kornbluth RS, Carson DA (Oct 1987) Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages., The Journal of Experimental Medicine, 166 (4), 1144-9.

Gregory SA, Kornbluth RS, Helin H, Remold HG, Edgington TS (Nov 1986) Monocyte procoagulant inducing factor: a lymphokine involved in the T cell-instructed monocyte procoagulant response to antigen., Journal of Immunology (baltimore, Md. : 1950), 137 (10), 3231-9.

Kornbluth RS, Edgington TS (Oct 1986) Tumor necrosis factor production by human monocytes is a regulated event: induction of TNF-alpha-mediated cellular cytotoxicity by endotoxin., Journal of Immunology (baltimore, Md. : 1950), 137 (8), 2585-91.

Osman MM, Kornbluth RS, Hosannah YT, Manahan J, Keller S, Mandl I, Turino GM (Jul 1982) A simple procedure for the isolation of pulmonary parenchyma free of major blood vessels and airways for biochemical studies., The American Review of Respiratory Disease, 126 (1), 156-9.

Kornbluth RS, Turino GM (Jan 1980) Respiratory control in diffuse interstitial lung disease and diseases of the pulmonary vasculature., Clinics in Chest Medicine, 1 (1), 91-102 Abstract